During the 2022 clinical rollout of nirmatrelvir in Israel, most patients (78%) had previous SARS-CoV-2 immunity. Benefit was seen in patients at highest risk for Covid-19 progression, such as those 65 years of age or older.

A randomized trial of bedaquiline–pretomanid–linezolid for highly drug-resistant tuberculosis assessed the use of linezolid at 600 or 1200 mg for 9 or 26 weeks; the 600-mg dose for 26 weeks had a favorable profile.

In a randomized trial involving patients who had undergone percutaneous coronary intervention, routine functional testing did not improve clinical outcomes at 2 years.

A 3-year-old boy presented with abdominal pain and vomiting. He had associated chills without fever, nonbloody and nonbilious emesis, constipation, reduced urinary output, and a decreased activity level. What is the diagnosis?

Lesions of the ovary and fallopian tube are common and may be acute or chronic. Diagnostic assessment is designed to distinguish benign from malignant causes. Referral to a gynecologic oncologist is often necessary.

The risks associated with alcohol consumption are well documented. Requiring new, well-designed warning labels on alcohol containers could provide information to consumers and reduce harm.

For patients with rare diseases, connecting virtually with specialists across state lines can be the only option for excellent care. So why are state-licensing restrictions being enforced more aggressively than ever?