- N Engl J Med 2022; 387:e15
A 13-year-old girl with blurry vision, painful eye movements, and weakness and paresthesias in her left leg was found to have a relative afferent pupillary defect in her left eye (shown in a video).
- N Engl J Med 2022; 387:757-759
Canadian data show that legalization of cannabis for adults has been associated with increased hospitalizations for unintentional cannabis poisoning in children, mostly after legalization of cannabis edibles.
- N Engl J Med 2022; 387:584-585
For professionals who work with children and adolescents, policies like Florida’s “Don’t Say Gay” law have outsized cruelty — even beyond the enormous harm they will do to the young people we serve.
- N Engl J Med 2022; 387:433-443
This trial compared once-weekly dulaglutide, a GLP-1 receptor agonist, with placebo for glycemic control in youths with type 2 diabetes who may have been receiving metformin or basal insulin. Dulaglutide was superior at 26 weeks.
- N Engl J Med 2022; 387:294-297
With policymakers targeting members of sexual and gender minority groups, the health care sector can mitigate resulting harm and advocate for evidence-based policies protecting health and well-being.
- N Engl J Med 2022; 386:2357-2359
Courts and physicians need to be mindful about the use and misuse of medical-science findings in constitutional conflicts, the cloaking of moral views in scientific guise, and the marshaling of medicine’s cultural authority as a means of persuasion.
- N Engl J Med 2022; 386:2161-2164
State efforts to prohibit gender-affirming care place physicians’ duties to avoid discrimination, protect privacy, meet standards of care, fulfill reporting requirements, and avoid committing crimes in direct conflict with one another.
- N Engl J Med 2022; 386:2222-2231
A 17-year-old boy was admitted to the pediatric ICU with chest pain, syncope, electrocardiographic abnormalities, and elevated creatine kinase and troponin T. He had been well until 5 days earlier, when fever, nausea, diarrhea, muscle aches, and chest pain developed.
- N Engl J Med 2022; 386:2169-2177
Microscopic and immunohistochemical examination revealed chronic traumatic encephalopathy in 10 of 225 brains (4.4%) from a military brain bank. The relative risks of CTE were calculated for exposure to blasts, traumatic brain injury, and previous participation in contact sports.
- N Engl J Med 2022; 386:2067-2069
Black girls in America are harmed by intersecting racism and sexism, which manifest in biases, stereotypes, and practices that render them vulnerable to abuse, dehumanization, and death. Our silence about Black girls has clinical consequences throughout their life span.
- N Engl J Med 2022; 386:2139-2140
Since the initial guidelines of the National Asthma Education and Prevention Program (NAEPP) were published in 1991,1 short-acting β2-agonists (SABAs) have been recommended as the preferred rescue therapy for patients with asthma of any severity. In the 2020 NAEPP update,2 for the first time,...
- N Engl J Med 2022; 386:2071-2083
Among patients with moderate-to-severe asthma who were receiving a range of inhaled glucocorticoid maintenance therapies, the risk of severe asthma exacerbation was significantly lower with as-needed use of a fixed-dose combination of 180 μg of albuterol and 160 μg of budesonide than with albuterol alone.
- N Engl J Med 2022; 386:2011-2023
In part 1 of a phase 2–3 trial, a 50-μg dose of mRNA-1273 vaccine was safe and immunogenic. In part 2, nearly 4000 6-to-11-year-olds received two doses of vaccine or placebo and were followed for a median of 82 days. The vaccine had mainly mild adverse effects and was immunogenic...
- N Engl J Med 2022; 386:1955-1956
Firearm-related injury is now the leading cause of death among children and teens. We continue to fail to protect our youth from a preventable cause of death.
- N Engl J Med 2022; 386:1922-1931
Childhood brain tumors were previously classified by histologic appearance and location. A new classification includes genetic changes, which have prognostic significance and may lead to therapeutic targets. This review focuses on pediatric gliomas, ependymomas, and medulloblastomas.
- N Engl J Med 2022; 386:1899-1909
In this study evaluating BNT162b2, vaccine effectiveness against hospitalization for Covid-19 in the delta-predominant period among adolescents 12 to 18 years of age was more than 90%; during the omicron period, vaccine effectiveness was 40% against hospitalization and 79% against critical illness. Vaccine effectiveness against hospitalization was 68% among children...
- N Engl J Med 2022; 386:e50
A 14-year-old boy with acute lymphoblastic leukemia who had been receiving maintenance chemotherapy presented with acute blurry vision. Examination showed premacular hemorrhages in both retinas.
- N Engl J Med 2022; 386:1581-1583
Although restricting access to nontobacco flavors of e-cigarettes may reduce vaping among adolescents and mitigate associated risks, it could also impede smoking cessation among adults, thereby increasing smoking-attributable mortality. But policy solutions could exist.
- N Engl J Med 2022; 386:e42
An asymptomatic 25-year-old man presented to the emergency department with abnormal results on a preemployment chest radiograph. Computed tomography of the chest revealed herniation of the right kidney, omentum, and intestines into the right thoracic cavity.
- N Engl J Med 2022; 386:1485-1487
For more than 60 years, motor vehicle crashes were the leading cause of injury-related death among young people. Beginning in 2017, however, firearm-related injuries took their place to become the most common cause of death from injury.