- N Engl J Med 2022; 387:658-660
A study of DNA sequencing of reproductive tissues (e.g., products of conception after miscarriage) to test for aneuploidy supports the use of this approach to guide prenatal and fertility care.
- N Engl J Med 2022; 387:388-390
Health systems and clinicians planning for a post-Roe America can look to Texas, which has already witnessed the impact of strict abortion bans on the provision of evidence-based, essential health care.
Navigating Loss of Abortion Services — A Large Academic Medical Center Prepares for the Overturn of Roe v. WadeN Engl J Med 2022; 386:2061-2064
With the overturn of Roe v. Wade appearing imminent, U.S. medical centers must prepare carefully to manage the systemwide impact of abortion’s criminalization.
- N Engl J Med 2022; 386:892-894
Nirsevimab is a monoclonal antibody targeting respiratory syncytial virus. In this trial, the safety of nirsevimab was assessed in infants eligible to receive palivizumab, including those born preterm (at 35 weeks of gestation or less) and those with congenital heart disease or chronic lung disease of prematurity. No safety concerns...
- N Engl J Med 2022; 386:757-767
In this population-based cohort study that included data on all live births in Brazil from 2015 to 2018, infants with congenital Zika syndrome had substantially higher mortality over the first 3 years of life than those without the syndrome.
- N Engl J Med 2021; 385:1292-1301
The Wnt proteins are soluble and secreted; they have fundamental roles in directing and maintaining cell behavior. This study implicates a gene critical to Wnt secretion in structural birth defects and provides proof of principle of pharmacologic amelioration in mouse models.
- N Engl J Med 2021; 385:847-849
Engineering a model of the developing heart with stem cells has proved challenging. A recent study, however, provides a foundation — a single-chambered “cardioid” — for the development of such a model.
- N Engl J Med 2021; 385:436-444
Congenital cytomegalovirus infection is a cause of serious perinatal complications. In this randomized trial involving 399 pregnant women, CMV hyperimmune globulin was found to provide no benefit with respect to congenital CMV infection or perinatal death.
- N Engl J Med 2021; 385:107-118
In this trial involving fetuses with severe left congenital diaphragmatic hernia, fetoscopic endoluminal tracheal occlusion at 27 to 29 weeks of gestation significantly increased survival to discharge, but it resulted in an increased incidence of preterm, prelabor rupture of membranes and preterm birth.
- N Engl J Med 2021; 385:119-129
In this randomized trial involving fetuses with moderate left congenital diaphragmatic hernia, fetoscopic endoluminal tracheal occlusion at 30 to 32 weeks of gestation did not significantly increase survival to discharge from a NICU or reduce the need for oxygen supplementation at 6 months, and it increased the risks of preterm,...
- N Engl J Med 2021; 385:177-178
The modern era of fetal surgical interventions began in the 1980s, when improved ultrasonographic imaging enabled prenatal detection of life-limiting birth defects.1 However, the rarity of many severe fetal anomalies, maternal complications associated with open fetal interventions, and the availability of effective, if imperfect, strategies for postnatal infant...
- N Engl J Med 2021; 384:e27
Respiratory distress developed in a neonate after delivery at 32 weeks of gestation. Endotracheal intubation was unsuccessful, and he died 4 hours after delivery. A postmortem esophagram obtained after the administration of barium showed tracheal agenesis and bronchoesophageal fistula.
- N Engl J Med 2020; 383:e131
The FDA’s Center for Drug Evaluation and Research has recommended withdrawing the approval of Makena for the prevention of recurrent preterm birth after a trial failed both to verify clinical benefit to neonates and to substantiate a reduction in preterm birth.
- N Engl J Med 2020; 383:537-545
In an epidemiologic study of the Zika virus outbreak in Columbia in 2015 and 2016, brain or eye defects were diagnosed in 93 of 5673 infants or fetuses (2%) carried by women with laboratory-confirmed Zika virus disease.
- N Engl J Med 2020; 382:835-844
A young man with polycythemia, reduced growth rate, persistent hypoglycemia, and mitochondrial defects first appearing at birth was found to have a synonymous homozygous mutation in VHL (c.222C→A) that created a cryptic splice site leading to the production of a truncated VHL protein.
- N Engl J Med 2019; 381:1444-1457
Zika is a mosquito-borne flavivirus that can cause congenital defects, including microcephaly. Although most Zika virus infections are asymptomatic, rash, fever, arthralgia, myalgia, and conjunctivitis can develop in some people. The Guillain–Barré syndrome occurs in 2 to 3 patients per 10,000 with Zika virus infection.
- N Engl J Med 2019; 381:1333-1346
In this report, the timing of isoniazid therapy to prevent tuberculosis in pregnant women with HIV infection was assessed. Intrapartum isoniazid treatment resulted in a higher incidence of adverse pregnancy outcomes than treatment during the postpartum period.