- N Engl J Med 2022; 387:799-809
In this study involving 1257 pregnancies among persons treated for HIV-1 infection during pregnancy, dolutegravir was better at suppressing viral loads than other regimens, without evident safety concerns.
- N Engl J Med 2022; 387:727-736
Lesions of the ovary and fallopian tube are common and may be acute or chronic. Diagnostic assessment is designed to distinguish benign from malignant causes. Referral to a gynecologic oncologist is often necessary.
- N Engl J Med 2022; 387:587-598
Pregnant women were assigned to be evaluated with lower or higher glycemic criteria for the diagnosis of gestational diabetes. Lower criteria did not reduce the risk of a large-for-gestational-age infant.
- N Engl J Med 2022; 387:652-654
In the first decade of this millennium, convincing data showing that screening for and treatment of gestational diabetes mellitus improve both maternal and fetal outcomes1,2 ended debates within the obstetrical community about the usefulness of screening for gestational diabetes. Essentially all U.S. professional societies now recommend universal biochemical...
- N Engl J Med 2022; 387:388-390
Health systems and clinicians planning for a post-Roe America can look to Texas, which has already witnessed the impact of strict abortion bans on the provision of evidence-based, essential health care.
- N Engl J Med 2022; 387:109-119
In this study, maternal vaccination with an mRNA vaccine during pregnancy was less common among infants hospitalized for Covid-19 than among controls. The effectiveness of maternal vaccination against Covid-19 hospitalization of infants was 52% overall and was greater when delta, rather than omicron, was predominant.
- N Engl J Med 2022; 387:178-179
The benefits of maternal vaccination to the infant through maternal antibody transfer across the placenta have long been recognized. In the 1870s, babies born to mothers who had received smallpox vaccination were unlikely to have smallpox early in life.1 Tetanus toxoid vaccination during pregnancy, along with improved hygiene...
- N Engl J Med 2022; 387:187-189
In this retrospective cohort study involving pregnant women, those who had been vaccinated against Covid-19 did not have a higher risk of clinically serious adverse events than those who were unvaccinated.
Navigating Loss of Abortion Services — A Large Academic Medical Center Prepares for the Overturn of Roe v. WadeN Engl J Med 2022; 386:2061-2064
With the overturn of Roe v. Wade appearing imminent, U.S. medical centers must prepare carefully to manage the systemwide impact of abortion’s criminalization.
- N Engl J Med 2022; 386:1817-1832
Preeclampsia complicates 2 to 4% of all pregnancies and accounts for about 46,000 maternal deaths and 500,000 fetal or newborn deaths each year. Antihypertensive agents and magnesium sulfate can help control the systemic manifestations of preeclampsia, which is usually resolved by delivery of the placenta.
- N Engl J Med 2022; 386:1781-1792
Pregnant women with mild chronic hypertension were randomly assigned to receive medication targeting a normal blood pressure (<140/90 mm Hg) or to receive no treatment unless severe hypertension (>160/105 mm Hg) developed. The incidence of adverse maternal and neonatal outcomes was significantly lower in the active-treatment group, without an increase...
- N Engl J Med 2022; 386:1846-1847
The latest data from the National Center for Health Statistics indicate that in 2019 more than 83,000 pregnant women in the United States had chronic hypertension that antedated their pregnancies.1 This number represents 2.2% of the more than 3.7 million births that were recorded that year. The rate...
- N Engl J Med 2022; 386:391-393
This interactive feature about infants born very prematurely offers a case vignette accompanied by two essays supporting resuscitation in all neonates born at 22 weeks’ gestation or selective resuscitation. Vote and comment at NEJM.org.
- N Engl J Med 2021; 385:2096-2100
This Sounding Board article discusses the absence of data to support the current widespread use of preimplantation genetic testing for aneuploidy as an example of a broader concern in reproductive medicine.
- N Engl J Med 2021; 385:2008-2010
In this case–control study performed with the use of registry data in Norway, there was no evidence of an increased risk of first-trimester pregnancy loss associated with Covid-19 vaccination during early pregnancy.
- N Engl J Med 2021; 385:1533-1535
In this updated analysis from the CDC v-safe pregnancy registry, the cumulative risk of pregnancy loss at 6 to less than 20 weeks of gestation after receipt of Covid-19 vaccination soon after conception or in early pregnancy was consistent with rates of pregnancy loss over the same gestational age range...
- N Engl J Med 2021; 385:1124-1124
A 26-year-old woman with two prior cesarean deliveries presented in preterm labor. Placental vessels were visualized on the uterine walls during surgery. Placenta increta was diagnosed by histopathological analysis.