Browse Correspondence

In this follow-up study involving two patients with POMC deficiency, treatment with the MC4R agonist setmelanotide resulted in a long-term reduction in body weight and BMI and induced satiety.

Investigators report findings from the use of an all-oral regimen of bedaquiline, pretomanid, and linezolid in patients in the United States with multidrug-resistant or extensively drug-resistant tuberculosis.

To the Editor: The perioperative use of antiplatelet and anticoagulant agents may vary among physicians.^1,2 Indeed, in the Perioperative Ischemic Evaluation–3 (POISE-3) trial conducted by Devereaux et al. (May 26 issue),³ the use of such agents was left to the discretion of the attending physician....

To the Editor: Nearly half the patients with Schimke immuno-osseous dysplasia (SIOD) may have vascular or neurologic problems, including headaches, transient ischemic attacks (TIAs), and cerebral ischemic events. These problems contribute to the morbidity and mortality associated with this condition.^1,2 Unfortunately, the underlying pathophysiology of vascular disease...

To the Editor: Mismatch-repair status and extended analyses of RAS mutations in patients with colorectal cancer can be predictive and prognostic.^1,2 Cercek et al. (June 23 issue)³ report a complete clinical response in 12 patients with locally advanced, mismatch repair–deficient rectal cancer after...

To the Editor: In the Conservative versus Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care (CLASSIC) trial, Meyhoff et al. (June 30 issue)¹ found similar numbers of death at 90 days in patients with septic shock who received resuscitation with a restrictive-fluid strategy (42.3%)...

To the Editor: Richeldi et al. (June 9 issue)¹ reported prompt stabilization in lung function in patients with idiopathic pulmonary fibrosis (IPF) who received a preferential phosphodiesterase 4B (PDE4B) inhibitor and a rapid decline in the forced vital capacity (FVC) in patients who received placebo. Over a...

To the Editor: The report by Fajgenbaum et al. (May 26 issue)¹ describes a patient with idiopathic multicentric Castleman’s disease (iMCD) with the TAFRO (thrombocytopenia, anasarca, fever or an elevated C-reactive protein level or both, renal insufficiency or reticulin fibrosis or both, and organomegaly) clinical subtype that...

To the Editor: Tie and colleagues (June 16 issue)¹ reported that basing decisions regarding adjuvant chemotherapy in stage II colon cancer on the presence of circulating tumor DNA (ctDNA) after surgery was noninferior to basing such decisions on standard clinicopathological features and that it reduced chemotherapy use...

Canadian data show that legalization of cannabis for adults has been associated with increased hospitalizations for unintentional cannabis poisoning in children, mostly after legalization of cannabis edibles.

To the Editor: In their article on the Chronic Hypertension and Pregnancy (CHAP) trial, Tita et al. (May 12 issue)1 report better pregnancy outcomes in women assigned to active treatment of mild chronic hypertension (blood-pressure goal, <140/90 mm Hg) than in those assigned to treatment only for severe hypertension, with...

To the Editor: In the MANDALA trial, Papi et al. (June 2 issue)¹ showed the superiority of high-dose budesonide–albuterol to albuterol as reliever therapy for reducing exacerbations in patients with uncontrolled moderate-to-severe asthma. Only 27% of the patients were receiving high-dose inhaled glucocorticoid–long-acting β₂ -agonist (LABA)...

To the Editor: The findings reported by Palefsky et al. (June 16 issue)¹ in the Anal Cancer–HSIL [high-grade squamous intraepithelial lesion] Outcomes Research (ANCHOR) trial provide proof of principle that high-resolution anoscopy–guided periodic ablation of HSIL reduces the risk of anal cancer among human immunodeficiency virus (HIV)–positive...

To the Editor: Sheridan et al. (June. 9 issue)¹ review the diagnosis and treatment of frostbite. The authors note that the first step in the management of frostbite is evaluation for trauma and hypothermia. Since hypothermia and frostbite frequently are concomitant, sudden cardiac arrest may occur when...

A study of DNA sequencing of reproductive tissues (e.g., products of conception after miscarriage) to test for aneuploidy supports the use of this approach to guide prenatal and fertility care.

To the Editor: In the CheckMate 816 trial, Forde and colleagues (May 26 issue)¹ concluded that neoadjuvant treatment with nivolumab did not impede the feasibility of surgery, which is the curative treatment for lung cancer. However, in the experimental group (in which patients received nivolumab plus platinum-based...

To the Editor: In their review article, Levey et al. (June 2 issue)¹ stress creatinine-based estimates of the glomerular filtration rate (eGFRcr) as first-line tools to evaluate kidney function in real-world practice. However, they scarcely addressed the effect of age-related changes in body composition on the eGFR,...

To the Editor: In their Perspective article, Marcus et al. (June 2 issue)¹ warn that provision of human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) by entities participating in the 340B Drug Pricing Program, when such provision relies on revenue from the prescription of brand-name drugs, may lead...