- N Engl J Med 2022; 387:737-737
A 61-year-old woman with primary biliary cholangitis and Raynaud’s phenomenon was referred to the rheumatology clinic. Tongue telangiectasias, puffy fingers, and nailfold capillary hemorrhage were present.
- N Engl J Med 2022; 387:715-726
In patients with rheumatoid arthritis, the monoclonal antibody against interleukin-6, olokizumab, was superior to placebo and noninferior to adalimumab at 12 weeks.
- N Engl J Med 2022; 387:e12
A 51-year-old man with chronic myeloid leukemia who was receiving treatment with nilotinib presented for follow-up with a report that his hair had turned from gray to its original brown color.
- N Engl J Med 2022; 387:547-556
A 31-year-old man was admitted with perianal and penile ulcers, rectal pain, and vesiculopustular rash. He had first noticed itchy white “bumps” around the anus 9 days earlier. A diagnostic test was performed.
- N Engl J Med 2022; 387:451-451
A 68-year-old woman living in Japan presented with a 5-day history of rash and fevers. She had been bitten by a tick 1 week earlier. Examination revealed a petechial rash and eschar on the ankle.
- N Engl J Med 2022; 387:321-331
Litifilimab, a blood dendritic cell antigen 2 antibody, was superior to placebo with regard to a measure of disease activity in cutaneous lupus erythematosus at 16 weeks.
- N Engl J Med 2022; 387:355-355
A 59-year-old woman with a history of smoking tobacco presented with a 5-month history of darkening of the skin on her palms. Velvety thickening on the palms and fingers was observed on physical examination.
- N Engl J Med 2022; 387:167-167
A 30-year-old man presented with a morbilliform rash and fever after taking an antimicrobial agent. Facial edema, eosinophilia, and elevated liver-enzyme levels developed later.
- N Engl J Med 2022; 387:66-66
A 31-year-old man presented with a painless genital rash. Physical examination showed a macular rash and painful lymphadenopathy in the right groin, as well as penile ulceration and umbilicated pustules.
- N Engl J Med 2022; 386:e58
A 27-year-old man presented to the dermatology clinic with an asymptomatic rash on his back, arms, and hands that had developed 1 week earlier. Pink-yellow papules were seen on examination. A blood sample was grossly lipemic.
- N Engl J Med 2022; 386:2129-2129
A 34-year-old woman presented with a 4-year history of progressive skin lesions and 3-month history of weight loss. Physical examination showed a symmetric distribution of clusters of pink-yellow papules that merged into branching projections on the trunk, buttocks, and all four limbs.
- N Engl J Med 2022; 386:2035-2035
A 40-year-old man presented with a foot rash, joint swelling, and low back pain after having recently had urethral discharge. Conjunctivitis, migratory glossitis, and circinate balanitis were also noted on examination.
- N Engl J Med 2022; 386:1687-1699
Alopecia areata is a distressing disorder of hair loss that is mediated partly by cytokines dependent on Janus kinases. The JAK1 and JAK2 inhibitor baricitinib reduced the extent of hair loss in two randomized trials over a period of 36 weeks.
- N Engl J Med 2022; 386:e49
A 53-year-old landscaper presented with a 4-month history of red, raised, itchy skin lesions on his left lower back and buttock. On examination, numerous verrucous nodules and plaques with crusting were seen.
- N Engl J Med 2022; 386:1751-1752
For many people, alopecia areata is a transient problem, in which small patches of hair loss recover spontaneously within a few months. But for others, the reality is rather different. An Italian study showed that one third of patients with scalp hair loss of 25 to 50% still had active...
- N Engl J Med 2022; 386:1668-1669
Data were pooled from 36 patients who received the anti–CTLA-4 antibody ipilimumab after metastatic melanoma progression during therapy with nivolumab (anti–PD-1) plus relatlimab (anti–LAG-3) to assess whether immunotherapies that target distinct checkpoints have different mechanisms of action. The findings suggest that cross-resistance emerges when tumors progress with immune checkpoint inhibitors.
- N Engl J Med 2022; 386:1559-1559
A 64-year-old man had mild diarrhea and an itchy, migratory, serpiginous rash develop after initiation of glucocorticoid therapy for malignant spinal cord compression.