- N Engl J Med 2022; 387:77-78
Since 1902, animals have been studied and occasionally used as sources of organs for transplantation, usually when human organs were unavailable. Clinical organ xenotransplantation invariably failed, whereas clinical organ allotransplantation rose to become a primary treatment for failure of the heart, kidneys, liver, and lungs. Still, a shortage of human...
- N Engl J Med 2022; 387:35-44
In this report, a porcine-to-human heart transplantation is described. Videos show transthoracic echocardiography in the patient who received the heart.
- N Engl J Med 2022; 387:79-82
In a recent case of xenotransplantation, now described in the Journal, a porcine heart was transplanted into a human patient, an advance made possible through genetic alterations in the animal donor.
- N Engl J Med 2022; 386:2138-2138
The editors announce a new article type, the Science behind the Study. The articles, which include illustrations and glossary terms, are meant to elucidate the scientific foundations of new clinical studies published in the Journal.
- N Engl J Med 2022; 386:1081-1082
Congenital hemophilia A (factor VIII deficiency) is a bleeding disorder that results from pathologic variants in the gene F8 on the X chromosome. Among persons with hemophilia, those with severe disease (i.e., a factor VIII activity level of <1%) have the highest risk of spontaneous and traumatic life- and limb-threatening...
- N Engl J Med 2022; 386:1013-1025
Patients with severe hemophilia A were treated with an adeno-associated virus construct containing coagulation factor VIII cDNA and followed for 1 to 3 years. Median factor VIII activity at 49 to 52 weeks was 24 IU per deciliter, and annualized bleeding rates decreased after treatment. Elevations in alanine aminotransferase were...