- PerspectiveAug 31, 202210.1056/NEJMp2211311
Intradermal JYNNEOS may safely provide populations that have been disproportionately affected by monkeypox with rapid access to a limited resource without sacrificing the level of immune response achieved.
- N Engl J Med 2022; 387:749-750
In this issue of the Journal, Thornhill et al. report on 528 persons with monkeypox in a cohort spanning 16 countries on five continents.1 The authors provide important demographic, epidemiologic, and clinical details on the largest reported cohort of patients in the latest emerging infectious disease...
- N Engl J Med 2022; 387:738-747
A 48-year-old woman was evaluated for abdominal pain. CT showed numerous liver lesions and lung cysts and nodules; liver biopsy revealed an eosinophilic inflammatory infiltrate. A diagnosis was made.
- N Engl J Med 2022; 387:679-691
In this report, 528 cases of monkeypox across 16 countries are described. Rash, mucosal lesions, fever, lethargy, and lymphadenopathy were common clinical findings. Few patients were hospitalized.
- N Engl J Med 2022; 387:661-662
A patient in whom Japanese encephalitis was diagnosed in February 2021 has been identified as a likely sentinel human case of the 2022 outbreak of the disease in Australia.
- N Engl J Med 2022; 387:579-581
Tecovirimat might speed resolution of monkeypox illness and improve outcomes, but how can we manage compassionate access to a drug whose safety and efficacy in humans have not been established?
- N Engl J Med 2022; 387:641-650
A 25-year-old woman was evaluated for worsening headaches, photophobia, nausea, vomiting, and blurred vision. MRI revealed hydrocephalus and leptomeningeal enhancement. CSF analysis revealed neutrophilic pleocytosis.
- N Engl J Med 2022; 387:599-610
In this trial involving overweight or obese outpatients with Covid-19, investigators found that none of three repurposed drugs (metformin, ivermectin, and fluvoxamine) reduced the risk of serious disease.
- N Engl J Med 2022; 387:654-655
In practicing evidence-based medicine, physicians use the best evidence currently available on safety and efficacy in making decisions on treatment choices for their patients. During the Covid-19 pandemic, some of the early treatment trials were rushed, leading to studies that were badly conducted1 or had too few patients.
- N Engl J Med 2022; 387:568-570
In this ongoing household cohort study in Nicaragua, previous SARS-CoV-2 infection during a second Covid-19 wave provided some protection against symptomatic Covid-19, with greater protection against severe illness.
- N Engl J Med 2022; 387:547-556
A 31-year-old man was admitted with perianal and penile ulcers, rectal pain, and vesiculopustular rash. He had first noticed itchy white “bumps” around the anus 9 days earlier. A diagnostic test was performed.
- N Engl J Med 2022; 387:451-451
A 68-year-old woman living in Japan presented with a 5-day history of rash and fevers. She had been bitten by a tick 1 week earlier. Examination revealed a petechial rash and eschar on the ankle.
- N Engl J Med 2022; 387:460-461
In 2020, a total of 241 million cases of malaria and 627,000 malaria-related deaths were reported.1 In this issue of the Journal, Wu and colleagues2 present a new approach to provide immune protection with a next-generation monoclonal antibody against Plasmodium falciparum malaria...
- N Engl J Med 2022; 387:397-407
This phase 1 trial examined an engineered monoclonal antibody, L9LS, targeting the sporozoite. L9LS protected against malaria infection in a human challenge model.
- N Engl J Med 2022; 387:462-465
Monoclonal antibodies are commonly used in the treatment of diseases, including cancer. A next-generation antibody for the prevention of malaria exploits different vulnerabilities of Plasmodium falciparum, the major cause of malaria.
- N Engl J Med 2022; 387:470-472
In this report, investigators in China identified a new henipavirus associated with a febrile human illness. This virus was also found in shrews.
- N Engl J Med 2022; 387:385-388
In light of the shortcomings of the haphazard U.S. approach to public health, laid bare by the Covid pandemic, a Commonwealth Fund commission is proposing urgent, necessary, and realistic reforms.
- N Engl J Med 2022; 387:260-260
A 26-year-old woman presented with sore throat, pain while swallowing, shortness of breath, and fever. Marked swelling of the posterior oropharynx was observed on physical examination, and CT of the neck was performed.
- N Engl J Med 2022; 387:167-167
A 30-year-old man presented with a morbilliform rash and fever after taking an antimicrobial agent. Facial edema, eosinophilia, and elevated liver-enzyme levels developed later.