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Rapid Nanopore Sequencing–Based Screen for Aneuploidy in Reproductive Care

A study of DNA sequencing of reproductive tissues (e.g., products of conception after miscarriage) to test for aneuploidy supports the use of this approach to guide prenatal and fertility care.

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Shan Wei, Ph.D.
Alexandre Djandji, M.S.
Miriam T. Lattin, B.A.
Odelia Nahum, M.Sc.
Nataly Hoffman, M.S.
Claudia Cujar, M.D.
Columbia University Irving Medical Center, New York, NY

Refik Kayali, Ph.D.
Igenomix Los Angeles, Torrance, CA

Cengiz Cinnioglu, Ph.D.
NextGen Genetics, Santa Clara, CA

Ronald Wapner, M.D.
Mary D’Alton, M.D.
Brynn Levy, M.Sc.(Med.), Ph.D.
Zev Williams, M.D., Ph.D.
Columbia University Irving Medical Center, New York, NY

Funding and Disclosures

Supported by grants from the National Institutes of Health (HD068546, U19CA179564, and HD100013, to Dr. Williams), the Biomedical Engineering Technology Accelerator (BioMedX) at Columbia University, and the Wendy and John Havens Innovation Fund.

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

Drs. Levy and Williams contributed equally to this letter.

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