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Nonoperative Management of Childhood Calvarial Langerhans-Cell Histiocytosis

In a prospective series of 17 children with Langerhans-cell histiocytosis of the skull, all the lesions resolved spontaneously by 1 year. This approach contrasts with the usual practice of surgery for these lesions.

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Paul Steinbok, M.B., B.S.
Alexander Cheong, M.Sc.
David B. Dix, M.B., Ch.B.
University of British Columbia, Vancouver, BC, Canada

Sanjiv Bhatia, M.D.
Nicklaus Children’s Hospital, Miami, FL

Michael H. Handler, M.D.
Children’s Hospital Colorado Anschutz Medical Campus, Aurora, CO

David D. Limbrick, Jr., M.D., Ph.D.
Washington University School of Medicine, St. Louis, MO

Toba Niazi, M.D.
Nicklaus Children’s Hospital, Miami, FL

Angela V. Price, M.D.
University of Texas Southwestern Medical Center, Dallas, TX

John Ragheb, M.D.
Nicklaus Children’s Hospital, Miami, FL

Mark Souweidane, M.D.
Weill Cornell Medical College, New York, NY

Mandeep S. Tamber, M.D., Ph.D.
University of British Columbia, Vancouver, BC, Canada

David I. Sandberg, M.D.
McGovern Medical School, Houston, TX

Funding and Disclosures

Supported by the Rare Disease Foundation.

Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.

Sanjiv Bhatia, M.D., is deceased.

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