In this follow-up study involving two patients with POMC deficiency, treatment with the MC4R agonist setmelanotide resulted in a long-term reduction in body weight and BMI and induced satiety.
Peter Kühnen, M.D.
Charité–Universitätsmedizin Berlin, Berlin, Germany
Karine Clément, M.D., Ph.D.
Sorbonne Université, Paris, France
Funding and Disclosures
The investigator-initiated study was supported by a
Disclosure forms provided by the authors are available with the full text of this letter at NEJM.org.
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