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Clinical Implications of Basic ResearchFree Preview

When Silence Disrupts

List of authors.
  • Ryan C. Hunt, M.D.,
  • and Chava Kimchi-Sarfaty, Ph.D.

Genomes have different types of genetic variation, and many changes are assumed to be “silent” — that is, they have no effect on biology, health, or fitness. A recent study shows that it is not that simple.

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Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Author Affiliations

From the Division of Plasma Protein Therapeutics, Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD.

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