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Case Records of the Massachusetts General HospitalFree Preview

Case 18-2022: A 29-Year-Old Woman with Recurrent Fractures

List of authors.
  • Michael J. Econs, M.D.,
  • Daryl J. Selen, M.D.,
  • Rene Balza, M.D.,
  • Omar Zurkiya, M.D., Ph.D.,
  • Henry M. Kronenberg, M.D.,
  • and Yin P. Hung, M.D., Ph.D.

A 29-year-old woman presented with recurrent bone fractures and hypophosphatemia. The patient had been well until 19 months before admission, when pain in the right foot developed. During the next 19 months, multiple fractures of the metatarsal bones of the right foot occurred. On admission, the blood phosphorus level was 1.0 mg per deciliter. A diagnostic test was performed.

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Funding and Disclosures

This case was presented at Medicine Grand Rounds.

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

We thank Dr. Michael Collins of the National Institutes of Health and Dr. Michael Mannstadt of Massachusetts General Hospital for their expert guidance in the care of this patient.

Author Affiliations

From the Department of Medicine, Indiana University School of Medicine, Indianapolis (M.J.E.); and the Departments of Medicine (D.J.S., H.M.K.), Radiology (R.B., O.Z.), and Pathology (Y.P.H.), Massachusetts General Hospital, and the Departments of Medicine (D.J.S., H.M.K.), Radiology (R.B., O.Z.), and Pathology (Y.P.H.), Harvard Medical School — both in Boston.

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