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Primary Hyperoxaluria

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  • Xiaotong Xie, M.D.,
  • and Xiaoliang Zhang, M.D., Ph.D.

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A 40-year-old man with end-stage kidney disease and calcium oxalate nephrolithiasis presented to the emergency department with joint pain. A workup was notable for nephrocalcinosis on imaging; dense, metaphyseal bands on radiography of the hands; and calcium deposition in the cornea and skin. A diagnosis of primary hyperoxaluria was made by means of genetic testing.


Xiaotong Xie, M.D.
Xiaoliang Zhang, M.D., Ph.D.
Zhongda Hospital Southeast University, Nanjing, China

Funding and Disclosures

This article was published on March 5, 2022, at NEJM.org.

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