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Neuromyelitis Optica Spectrum Disorder

List of authors.
  • Dean M. Wingerchuk, M.D.,
  • and Claudia F. Lucchinetti, M.D.

Formerly known as Devic’s disease, this relapsing, demyelinating disorder of the central nervous system encompasses six syndromes and is associated with aquaporin-4 autoantibodies. Effective treatment prevents relapses.

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Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

We thank Mr. Seth Lambert and Mr. Bryce Bergene, Mayo Clinic, for assistance with earlier versions of the figures.

Author Affiliations

From the Department of Neurology, Mayo Clinic, Scottsdale, AZ (D.M.W.); and the Department of Neurology, Mayo Clinic, Rochester, MN (C.F.L.).

Dr. Wingerchuk can be contacted at or at the Department of Neurology, Mayo Clinic, 13400 E. Shea Blvd., Scottsdale, AZ 85259.

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