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Extracorporeal Kidney-Replacement Therapy for Acute Kidney Injury

List of authors.
  • Stéphane Gaudry, M.D., Ph.D.,
  • Paul M. Palevsky, M.D.,
  • and Didier Dreyfuss, M.D.

Acute kidney injury can be accompanied by life-threatening electrolyte and metabolic abnormalities. Kidney-replacement therapy may be urgently needed to prevent death from uremia. This review considers treatment approaches, indications, and intensity in critically ill patients with AKI.

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Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Drs. Palevsky and Dreyfuss contributed equally to this article.

Author Affiliations

From INSERM, UMR_S1155, Common and Rare Kidney Diseases, Hôpital Tenon, Sorbonne Université (S.G., D.D.), and Université de Paris (D.D.), Paris, Assistance Publique–Hôpitaux de Paris, Hôpital Avicenne, Service de Réanimation Médico-Chirurgicale, and the Health Care Simulation Center, UFR SMBH, Université Paris 13, Sorbonne Paris Cité, Bobigny (S.G.), and Assistance Publique–Hôpitaux de Paris, Service de Médecine Intensive-Réanimation, Hôpital Louis Mourier, Colombes (D.D.) — all in France; and the Kidney Medicine Section, Medical Service, Veterans Affairs Pittsburgh Healthcare System, and the Renal-Electrolyte Division, Department of Medicine, University of Pittsburgh — both in Pittsburgh (P.M.P.).

Dr. Dreyfuss can be contacted at or at Unité INSERM, Common and Rare Kidney Diseases, Hôpital Tenon, 4 rue de la Chine, 75020 Paris, France.

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