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Laboratory Diagnosis of Creutzfeldt–Jakob Disease

List of authors.
  • Inga Zerr, M.D.

The diagnosis of Creutzfeldt–Jakob disease has advanced from detection of characteristic EEG and MRI features to include the detection in CSF of 14-3-3 protein and, with the use of RT-QuIC assays, of abnormally folded prion protein, with close to 100% sensitivity and specificity.

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Funding and Disclosures

Disclosure forms provided by the author are available with the full text of this article at NEJM.org.

Author Affiliations

From the National Reference Center for Human Prion Diseases, Clinical Dementia Center, Department of Neurology, University Medical Center, Georg August University, Göttingen, Germany.

Dr. Zerr can be contacted at or at the National Reference Center for Human Prion Diseases, Clinical Dementia Center, Department of Neurology, University Medical Center, Georg August University, 37099 Göttingen, Germany.

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