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Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition

List of authors.
  • Rosario Notaro, M.D.,
  • and Lucio Luzzatto, M.D.

Inhibitors of proximal and terminal complement cascades can often control red-cell hemolysis associated with paroxysmal nocturnal hemoglobinuria, but some patients have breakthrough hemolysis.

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Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Author Affiliations

From Istituto per lo Studio, la Prevenzione e la Rete Oncologica (R.N.), and the University of Florence (L.L.) — both in Florence, Italy; and the Department of Hematology and Blood Transfusion, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania (L.L.).

Dr. Notaro can be contacted at or at Istituto per lo Studio, la Prevenzione e la Rete Oncologica, Viale Pieraccini 6, Edificio 27b, 50139 Florence, Italy.

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