- N Engl J Med 2022; 387:833-838
A 3-year-old boy presented with abdominal pain and vomiting. He had associated chills without fever, nonbloody and nonbilious emesis, constipation, reduced urinary output, and a decreased activity level.
- N Engl J Med 2022; 387:737-737
A 61-year-old woman with primary biliary cholangitis and Raynaud’s phenomenon was referred to the rheumatology clinic. Tongue telangiectasias, puffy fingers, and nailfold capillary hemorrhage were present.
- N Engl J Med 2022; 387:715-726
In patients with rheumatoid arthritis, the monoclonal antibody against interleukin-6, olokizumab, was superior to placebo and noninferior to adalimumab at 12 weeks.
- N Engl J Med 2022; 387:631-639
Formerly known as Devic’s disease, this relapsing, demyelinating disorder of the central nervous system encompasses six syndromes and is associated with aquaporin-4 autoantibodies. Effective treatment prevents relapses.
- N Engl J Med 2022; 387:e14
A 74-year-old woman with psoriatic arthritis presented with swelling of the fifth finger. On examination, there were nontender, subcutaneous nodules in the hypothenar region and over the fifth finger.
- N Engl J Med 2022; 387:368-370
An estimated one third or more of U.S. adults 60 years of age or older take vitamin D supplements, not including those who take multivitamins or other compounds containing vitamin D.1 Yet controversy continues about its overall benefits. In this issue of the Journal, LeBoff and...
- N Engl J Med 2022; 387:321-331
Litifilimab, a blood dendritic cell antigen 2 antibody, was superior to placebo with regard to a measure of disease activity in cutaneous lupus erythematosus at 16 weeks.
- N Engl J Med 2022; 387:299-309
A study ancillary to a large trial showed that supplemental vitamin D3 did not lower the risk of fractures among generally healthy midlife and older adults not selected for vitamin D deficiency, low bone mass, or osteoporosis.
- N Engl J Med 2022; 387:168-176
A 17-year-old girl was admitted because of prolonged fever and cough. She had an elevated creatinine level and a low hemoglobin level. A diagnostic test was performed.
- N Engl J Med 2022; 387:67-73
A previously healthy 18-year-old woman presented to a primary care provider with a 2-month history of headaches and midscapular pain. The midscapular pain was worse at night and lessened with exercise.
- N Engl J Med 2022; 386:2532-2534
In a prospective series of 17 children with Langerhans-cell histiocytosis of the skull, all the lesions resolved spontaneously by 1 year. This approach contrasts with the usual practice of surgery for these lesions.
- N Engl J Med 2022; 386:2359-2361
The rheumatologist had been drawn to her specialty by the diagnostic mysteries and long-term patient relationships, but faced with Mr. C., she found herself failing not only to diagnose his condition but also to keep him out of the hospital as his condition deteriorated.
- N Engl J Med 2022; 386:2316-2326
A 29-year-old woman presented with recurrent bone fractures and hypophosphatemia. The patient had been well until 19 months before admission, when pain in the right foot developed. During the next 19 months, multiple fractures of the metatarsal bones of the right foot occurred. On admission, the blood phosphorus level was...
- N Engl J Med 2022; 386:2315-2315
A 67-year-old man presented to the ophthalmology clinic with swollen eyelids and proptosis. Biopsy of the right lacrimal gland showed a lymphoplasmacytic infiltrate with IgG4-positive plasma cells.
- N Engl J Med 2022; 386:2222-2231
A 17-year-old boy was admitted to the pediatric ICU with chest pain, syncope, electrocardiographic abnormalities, and elevated creatine kinase and troponin T. He had been well until 5 days earlier, when fever, nausea, diarrhea, muscle aches, and chest pain developed.
- N Engl J Med 2022; 386:2221-2221
A 68-year-old man presented with a 2-month history of eye pain, redness, and blurry vision. He also had a 1-year history of dry cough, sinusitis, and unintentional weight loss. CT of the chest revealed lung nodules.
- N Engl J Med 2022; 386:2035-2035
A 40-year-old man presented with a foot rash, joint swelling, and low back pain after having recently had urethral discharge. Conjunctivitis, migratory glossitis, and circinate balanitis were also noted on examination.