The use of e-cigarettes has increased rapidly. Although vaping has been shown to assist with smoking cessation, cases of severe vaping-related pulmonary disease and a number of deaths have recently been reported. Here we present a collection of articles and other resources on e-cigarettes and vaping-related disease, including clinical reports and commentary.
Deaths Due to E-Cigarette– or Vaping-Associated Lung Injury
A.K. Werner and Others
This study from the CDC compared the characteristics of 60 patients who died from EVALI with those of 2558 patients who were hospitalized for the condition but survived. The deaths were reported from 27 states and the District of Columbia, and most were associated with vaping THC-containing products before symptom onset.Apr 23
- Original Article Deaths Due to E-Cigarette– or Vaping-Associated Lung Injury A.K. Werner and Others
Disposable E-Cigarette Use among U.S. Youth
T.W. Wang and Others
Despite efforts to curtail the use of e-cigarettes among youth, millions of middle and high school students use them. This study, which compares use in 2019 with use in 2020, shows that despite an overall decline, an increasing percentage of these students report using disposable e-cigarettes.Mar 16
Vaping-Induced Lung Injury
J.E. Layden and Others
Vaping use has rapidly increased. In this final report from the Wisconsin and Illinois departments of public health, a severe respiratory illness in otherwise healthy young people is described. Of the 98 case patients identified in this investigation, 95% were hospitalized, 26% were intubated, and 2 persons died.Mar 05
Correspondence Imaging of Vaping-Associated Lung Disease
Correspondence Pulmonary Lipid-Laden Macrophages and Vaping
Correspondence Trends in Adolescent Vaping, 2017–2019
Correspondence Pulmonary Illness Related to E-Cigarette Use
Correspondence Pulmonary Disease Related to E-Cigarette Use
Editorial Vaping-Induced Acute Lung Injury
- Correspondence Disposable E-Cigarette Use among U.S. Youth T.W. Wang and Others
Characteristics of EVALI Patients Who Were Rehospitalized or Died after Discharge
A report and clinical guidance in the Center for Disease Control’s (CDC) Morbidity and Mortality Weekly Reports (MMWR) published on Friday, December 20, emphasize the risk of death or recurrent hospitalization due to e-cigarette, or vaping, product use–associated lung injury (EVALI).
Among the 1139 patients with EVALI discharged on or before October 31, 2019, 31 (2.7%) were rehospitalized a median of 4 days after discharge and with half of the events occurring between 2 and 20 days after discharge. Seven patients, five of whom were women, died outside the hospital. All patients who died had been in an intensive care unit (ICU) during hospitalization. The deaths occurred a median of 3 days after discharge. The median age of patients who died after discharge was 54 years, as compared with 23 years among patients with no rehospitalizations. Patients with EVALI who required rehospitalization or who died after discharge were more likely to have cardiac disease, chronic obstructive pulmonary disease (COPD), obstructive sleep apnea (OSA), diabetes mellitus, and multiple chronic comorbidities.
The clinical guidance urges health care professionals to work with appropriate staff to ensure that all patients discharged after treatment for EVALI are reevaluated at 48 hours, especially those who have been in an ICU, have social support networks in place to monitor their health, to ensure that post-discharge medications, such as glucocorticoids on taper and medications for known comorbid conditions, are taken appropriately, and that they do not resume use of vaping or combustible tobacco.
See the MMWR reports for full details:
Characteristics of Patients Experiencing Rehospitalization or Death After Hospital Discharge in a Nationwide Outbreak of E-cigarette, or Vaping, Product Use–Associated Lung Injury — United States, 2019
Update: Interim Guidance for Health Care Professionals Evaluating and Caring for Patients with Suspected E-cigarette, or Vaping, Product Use–Associated Lung Injury and for Reducing the Risk for Rehospitalization and Death Following Hospital Discharge — United States, December 2019